OFFICE OF DEFENSE NUCLEAR NONPROLIFERATION
Vision: We are committed to making the world a safer place by reducing nuclear and radiological dangers.
Mission: To develop and implement policy and technical solutions to eliminate proliferation-sensitive materials and limit or prevent the spread of materials, technology, and expertise related to nuclear and radiological weapons and programs around the world.
- Remove, eliminate, and minimize the use of proliferation-sensitive materials.
- Safeguard and secure materials, technologies, and facilities.
- Detect and prevent the illicit trafficking of nuclear/radiological materials, technology, information and expertise.
- Provide R&D technology solutions for treaty monitoring, minimizing the use of proliferation-sensitive materials, and the application of safeguards and security.
- Provide unique technical/policy solutions and develop programs/strategies to reduce nuclear/radiological dangers.
Global Threat Reduction Initiative 
The mission of the Global Threat Reduction Initiative (GTRI) is to reduce and protect vulnerable nuclear and radiological material located at civilian sites worldwide. GTRI supports the U.S. Department of Energy’s nuclear security goal by preventing terrorists from acquiring nuclear and radiological materials that could be used in weapons of mass destruction or other acts of terrorism. GTRI works towards achieving its mission by converting research reactors and isotope production facilities from the use of highly enriched uranium (HEU) to low enriched uranium (LEU), removing and/or disposing of excess nuclear and radiological materials, and protecting high-priority nuclear and radiological materials from theft. Together, these efforts provide a comprehensive approach to preventing terrorists’ access to nuclear and radiological materials.
Research and Development 
The Office of Defense Nuclear Nonproliferation Research and Development (DNN R&D) develops technical capabilities that reduce the threat to national security posed by nuclear weapons proliferation and illicit nuclear material trafficking.
Nonproliferation & International Security 
Working alongside NNSA’s interagency and international partners, the Office of Nonproliferation and International Security (NIS) provides leadership in the formulation and implementation of nonproliferation strategies to help achieve the Administration’s objectives, deploying a distinctive array of technically-based national security programs. To fulfill its role, NIS draws on and contributes to a wide range of technical resources within the U.S. National Laboratory complex and international organizations while working in concert with more than 70 countries.
International Material Protection & Cooperation 
The Office of International Material Protection and Cooperation (IMPC) is responsible for enhancing the security of vulnerable stockpiles of nuclear weapons and weapons-usable nuclear material in countries of concern and for improving the ability to detect the illicit trafficking of those materials.
Fissile Materials Disposition 
The mission of the Office of Fissile Materials Disposition (FMD) is to eliminate inventories of surplus weapon-grade plutonium and HEU in the United States and to support the elimination of surplus weapon-grade plutonium in Russia. Eliminating this material ensures that it can never again be readily used in nuclear weapons and reduces the risk of nuclear terrorism from theft or diversion of weapon-grade material.